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Expedite Wound Closure With

Amniotic TISSUE
Use as protective wound barrier to providing an antimicrobial,
growth factor rich healing environment
Promotes native tissue repair by minimizing fibrosis, reducing inflammation,
and maximizing patient comfort

Expedite wound closure between 4-6 weeks on average.
Natural Biosynthetic Products
Treatment of Diabetic Ulcers, Venous Stasis Ulcer, Pressure Sores, Trauma Wounds and Burns
Expedited Wound Closure for Pain Reduction and Infection Control


A potential alternative to leg amputation, healing with native tissue and less scarring
Non-healing ulcer
Throughout treatment
Closure
Diabetic foot ulcer patients are twice as costly to US Medicare as those with diabetes alone.
The average cost of wound care is 10,000 - 20,000.
The average cost to lower limb amputation is 73,000 - 120,000.


Axolotl Ambient™️ is an ambient temperature (25±7°C, 77±13°F) stored liquid allograft derived from components of the placenta.
Axolotl Ambient™️ contains growth factors and cytokines secreted from birth tissue-derived cells:
QUALITY ASSURANCE
Axolotl Ambient™️ allograf tissue products have been manufactured using the BioSymTM process which includes, cleaning as well as terminal sterilization steps. This process was established in accordance with FDA regulations and has been subjected to testing and validation studies to verify effectiveness.
Axolotl Ambient™️ is only intended for use in the domestic United States.



Axolotl Ambient™ allograf tissue products have been manufactured using the BioSym™ process which includes, cleaning as well as terminal sterilization steps. This process was established in accordance with FDA regulations and has been subjected to testing and validation studies to verify effectiveness.
Axolotl Ambient™ is only intended for use in the domestic United States.
AXOLOTL GRAFT™
PRODUCT & BENEFITS
Axolotl Graft™ is a dehydrated human amnion membrane allograft (dhAM) derived from the amniotic lining of the placenta. Axolotl Graft™ is indicated as a barrier and selective membrane but has properties known to advance soft tissue repair and reconstruction1. Axolotl Graft™ is marketed under Section 361 of the PHS act and regulated under 21 CFR Part 1271.
The amniotic components used in Axolotl Graft™ create a natural 3- D extracellular matrix scaffold for cellular attachment and creates an environment to allow for cell migration1. Axolotl Graft™ is processed through minimally manipulated techniques. This type of processing retains the qualities of the native ECM allowing Axolotl Graft™ to aid in cellular chemotaxis and ingrowth2.
Proteins found in Axolotl Graft™ include:
-Collagen I, III, IV, V and VII -Fibronectin
-Laminin
AXOLOTL DUALGRAFT™
PRODUCT & BENEFITS
Axolotl DualGraft™ is a bi-layered dehydrated human amnion membrane allograft (dhAM) derived from the amniotic lining of the placenta. Axolotl DualGraft™ is indicated as a barrier and selective membrane but has properties known to advance soft tissue repair and reconstruction1. Axolotl DualGraft™ simplifies the application process by positioning the epithelial surfaces facing outwards, eliminating application placement limitations. Axolotl DualGraft™ is marketed under Section 361 of the PHS act and regulated under 21 CFR Part 1271.
The amniotic components used in Axolotl DualGraft™ create a natural 3-D extracellular matrix scaffold for cellular attachment and creates an environment to allow for cell migration1. Axolotl DualGraft™ is processed through minimally manipulated techniques. This type of processing retains the qualities of the native ECM allowing Axolotl DualGraft™ to aid in cellular chemotaxis and ingrowth2.
Proteins found in Axolotl DualGraftTM include: -Collagen I, III, IV, V and VII
-Fibronectin
-Laminin
EFFICIENT
Procedures are efficient and do not require special instrumentation.
NATURAL
The active contents in Axolotl Grafts are found naturally in the body.
QUALITY ASSURANCE
The donor tissue is recovered and processed under sterile conditions, in accordance with all FDA guidelines and quality assurance standards in a controlled environment. Axolotl Graft™ allograft tissue products are terminally irradiated in the final package. Axolotl Graft™ is only intended for use in the domestic United States



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Rocha, S. C. M., & Baptista, C. J. M. (2015). Biochemical properties of amniotic membrane. In Amniotic Membrane (pp. 19-40). Springer, Dordrecht.
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Lintzeris, D., Yarrow, K., Johnson, L., White, A., Hampton, A., Strickland, A., ... & Cook, A. (2015). Use of a Dehydrated Amniotic Membrane Allograft on Lower Extremity Ulcers in Patients with Challenging Wounds: A Retrospective Case Series. Ostomy/ wound management, 61(10), 30-36.


A Powerful Regenerative Wound Matrix to Support Acute and Chronic Wound Closure
DermacyteTM products are derived from human postpartum amniotic tissues that have been processed to retain native extracellular matrix cytokines, growth factors, and collagen to support tissue remolding, improving patient outcomes and treatment comfort and are offered in a Liquid and Matrix form.
Easy to Use
Ready for Application
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Dehydrated for easy application with no refrigeration
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No preparation time required for thawing or soaking reducing operative time
Easy to Handle
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Conforms to wound bed and naturally hydrates in place
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Superior handling and optimal bioabsorption properties
Improved Patient Experience
Use as protective wound barrier to provide an antimicrobial, growth factor rich healing environment

Promotes native tissue repair by minimizing fibrosis, reducing inflammation, and maximizing patient comfort
Simple Wound Monitoring
Routine dressing changes, wound cleansing, and Dermacyte reapplication allows for easy assessment of wound closure.
Committed to Patient Safety
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All tissues are recovered and processed by a U.S. FDA registered and AATB accredited tissue bank
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A Licensed Medical Director confirms product eligibility through donor screening and testing records, and final culturing and sterility testing is confirmed prior to lot release
Clinical Applications
Dermacyte products are versatile coverings and void fillers that may be applied to various hard-to-heal wounds, including:
• Diabetic foot ulcers
• Venous stasis ulcers
• Burns
• Decubitus / Pressure Ulcers
• Surgical incisions
• Other dermal defects and wounds
Dermacyte
A Unique Bioactive Wound Covering
Scaffolds:
The special structure and biological viability of amniotic membrane is ideal in tissue engineering. The extracellular matrix components of the basement membrane creates a natural scaffold for cell attachment. 1

Signals:
Amniotic tissue is rich in cytokines, growth factors, and stem cells that play a role in improved healing and regeneration and decreased immunogenicity. 2

Cells:
Sufficient cues to allow for cell attachment and proliferation are properties of dehydrated amnion. Soluble factors secreted by human dermal fibroblasts cultured on amnion enhanced both endothelial cell and keratino- cyte survival and endothelial cell migration in a wound closure assay. 3

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